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規(guī)格	庫存	目錄價(jià)	會(huì)員專享價(jià)	數(shù)量
1 mg	In-stock	￥446.00	登錄后可見	- +
5 mg	In-stock	￥1066.00	登錄后可見	- +
10 mg	In-stock	￥1748.00	登錄后可見	- +
25 mg	In-stock	￥2688.00	登錄后可見	- +
50 mg	In-stock	￥4188.00	登錄后可見	- +
100 mg	In-stock	￥6866.00	登錄后可見	- +
250 mg	In-stock	￥9866.00	登錄后可見	- +
500 mg	In-stock	￥14660.00	登錄后可見	- +
1 g	In-stock	￥21666.00	登錄后可見	- +

規(guī)格

庫存

目錄價(jià)

會(huì)員專享價(jià)

數(shù)量

1 mg

In-stock

￥446.00

登錄后可見

- +

5 mg

In-stock

￥1066.00

登錄后可見

- +

10 mg

In-stock

￥1748.00

登錄后可見

- +

25 mg

In-stock

￥2688.00

登錄后可見

- +

50 mg

In-stock

￥4188.00

登錄后可見

- +

100 mg

In-stock

￥6866.00

登錄后可見

- +

250 mg

In-stock

￥9866.00

登錄后可見

- +

500 mg

In-stock

￥14660.00

登錄后可見

- +

1 g

In-stock

￥21666.00

登錄后可見

- +

基本信息

英文名稱	Abrocitinib (Synonyms: PF-04965842; N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide \| N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}-propane-1-sulfonamide)
中文名稱	N-(順式-3-(甲基(7H-吡咯并[2,3-d]嘧啶-4-基)氨基)環(huán)丁基)丙烷-1-磺酰胺;阿布昔替尼; 阿布羅替尼;
CAS號	1622902-68-4
分子式	C14H21N5O2S
分子量	323.41
MDL	MFCD30187577
外觀	White to off-white powder
儲(chǔ)存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC₅₀s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC₅₀, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease.

相關(guān)文獻(xiàn)

Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.

PMID: 29298069 DOI: 10.1021/acs.jmedchem.7b01598

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瀏覽記錄

CL2918

N-(順式-3-(甲基(7H-吡咯并[2,3-d]嘧啶-4-基)氨基)環(huán)丁基)丙烷-1-磺酰胺;阿布昔替尼; 阿布羅替尼;

1622902-68-4 Purity: 99.08% In-stock

￥446.00 1 mg

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N-(順式-3-(甲基(7H-吡咯并[2,3-d]嘧啶-4-基)氨基)環(huán)丁基)丙烷-1-磺酰胺;阿布昔替尼; 阿布羅替尼;

Abrocitinib (Synonyms: PF-04965842; N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide | N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}-propane-1-sulfonamide)

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